When should antiretroviral therapy (ART) be initiated for HIV infection?

Updated: Jul 01, 2019
  • Author: Nicholas John Bennett, MBBCh, PhD, MA(Cantab), FAAP; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Research data led to US guidelines recommending that antiretroviral therapy be initiated at a CD4 count threshold of 350/μL, although 2013 guidelines from the World Health Organization (WHO) now recommend a threshold of 500/μL. [109, 110] They also state that in some cases, antiretroviral treatment should begin immediately, regardless of the CD4 count, including in HIV-positive serodiscordant couples, patients with hepatitis-B coinfection, pregnant or breastfeeding women, and children under age 5 years. [109, 110]


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