What have the studies of T-cell–replication kinetics revealed about HIV infection?

Updated: Jul 27, 2020
  • Author: Shelley A Gilroy, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Studies of T-cell–replication kinetics have revealed that untreated HIV infection is characterized by rapid T-cell turnover but a defect in T-cell replication from the thymus. [39, 40, 41] These changes can be reversed with effective long-term antiviral therapy, [42, 43] suggesting that they are due to a direct effect of the virus or are a feature of the immune response against HIV.


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