What is a feature of HIV replication in GALT?

Updated: Mar 05, 2020
  • Author: Shelley A Gilroy, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

A feature of HIV replication in GALT is that it is compartmentalized, even among different areas of the gut. [34] Measurements of CD4+ T cells in GALT show relatively less reconstitution with antiretroviral therapy than that observed in peripheral blood. [35, 36] At least one report has suggested that early treatment may result in better GALT CD4+ T-cell recovery, [36] but clinical data generally argue against early initiation of therapy, which has not been shown to improve long-term survival.

In addition, HIV replication can be detected even in patients with supposedly suppressed replication, as judged by plasma viral load measurements. CD8+ killer T-cell responses to HIV occur in GALT and do not decline with antiviral therapy as much as peripheral measurements do. [37] These findings underscore the limitations of peripheral measurements in what is really a central viral replication.


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