What are the CDC recommended HIV postexposure prophylaxis (PEP) and pre-exposure prophylaxis (PrEP) regimens?

Updated: Jul 27, 2020
  • Author: Shelley A Gilroy, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

The CDC has recommended HIV postexposure prophylaxis (PEP) and HIV pre-exposure prophylaxis (PrEP) regimens. [12]

PEP drug regimens are as follows:

  • Preferred option 1: Dolutegravir plus tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) (Truvada)
  • Preferred option 2: Raltegravir plus Truvada (TDF/FTC)
  • Alternative: Truvada (TDF/FTC ) plus darunavir (Prezista) plus ritonavir daily

PrEP drug regimens are as follows:

  • Preferred PrEP drug regimen: Truvada (TDF/FTC)
  • Alternative: Descovy (TAF/FTC)

See HIV Infection and AIDS Treatment & Management for more detail.


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