When is prophylaxis against opportunistic infections indicated in the management of HIV infection?

Updated: Jul 01, 2019
  • Author: Nicholas John Bennett, MBBCh, PhD, MA(Cantab), FAAP; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

In particular cases, prophylaxis is indicated for specific opportunistic infections, including the following:

  • Pneumocystis jiroveci

  • Toxoplasma

  • Mycobacterium avium complex

  • Fungal and viral infections: Although prophylaxis for these infections is not routinely necessary, some recommend fluconazole in patients with CD4+ T-cell counts under 50/µL to prevent candidal or cryptococcal infections and to protect against endemic fungal infections; oral ganciclovir is indicated for CMV prophylaxis in patients with advanced AIDS


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