When is prophylaxis against opportunistic infections indicated in the management of HIV infection?

Updated: Mar 05, 2020
  • Author: Shelley A Gilroy, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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In particular cases, prophylaxis is indicated for specific opportunistic infections, including the following:

  • Pneumocystis jiroveci

  • Toxoplasma

  • Mycobacterium avium complex

  • Fungal and viral infections: Although prophylaxis for these infections is not routinely necessary, some recommend fluconazole in patients with CD4+ T-cell counts under 50/µL to prevent candidal or cryptococcal infections and to protect against endemic fungal infections; oral ganciclovir is indicated for CMV prophylaxis in patients with advanced AIDS

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