When is prophylaxis against opportunistic infections indicated in the management of HIV infection?

Updated: Jul 27, 2020
  • Author: Shelley A Gilroy, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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In particular cases, prophylaxis is indicated for specific opportunistic infections, including the following:

  • Pneumocystis jiroveci
  • Toxoplasma
  • Mycobacterium avium complex
  • Fungal and viral infections: Although prophylaxis for these infections is not routinely necessary, some recommend fluconazole in patients with CD4 + T-cell counts under 50/µL to protect against cryptococcosis and endemic fungal infections. Oral fluconazole is not recommended for routine primary prophylaxis against Candida infection. Administration of ART and immune restoration are effective for preventing disease. Oral valganciclovir primary prophylaxis for CMV infection is not recommended in patients who will be receiving or are not receiving ART. [12]

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