Which medications in the drug class HIV, Attachment Inhibitors are used in the treatment of HIV Infection and AIDS?

Updated: Jul 27, 2020
  • Author: Shelley A Gilroy, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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HIV, Attachment Inhibitors

HIV-1 attachment inhibitors decrease viral replication by binding directly to the glycoprotein 120 (gp120) subunit on the surface of the virus.

Fostemsavir (Rukobia)

Prodrug of temsavir, a first-in-class glycoprotein 120 (gp120) attachment inhibitor. Binds directly to the gp120 subunit on surface of the virus, thereby blocking HIV from attaching to host immune system CD4+ T cells and other immune cells. It is indicated in combination with other ATV drugs for the treatment of HIV-1 infection in heavily treatment-experienced adults with multidrug-resistant HIV-1 infection failing their current ART regimen owing to resistance, intolerance, or safety considerations.

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