What is the prognosis of primary lateral sclerosis (PLS)?

Updated: Apr 28, 2014
  • Author: Hidehiro Takei, MD; Chief Editor: Adekunle M Adesina, MD, PhD  more...
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Unlike ALS, clinically pure primary lateral sclerosis (PLS), defined by isolated upper motor neuron (UMN) signs 4 years after symptom onset, progresses slowly, and patients maintain high levels of independence for years or decades. [64] UMN-dominant ALS (ie, predominantly UMN disease with minor lower motor neuron [LMN] signs) presents with disability similar to that of ALS but progresses more slowly. [64]

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