Which immunohistochemical findings are characteristic of primary lateral sclerosis (PLS)?

Updated: Apr 28, 2014
  • Author: Hidehiro Takei, MD; Chief Editor: Adekunle M Adesina, MD, PhD  more...
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Answer

Answer

No characteristic immunohistochemical findings are noted in primary lateral sclerosis (PLS). When ubiquitin-immunoreactive inclusions are identified in the lower motor neurons (LMNs), ALS may be much more likely than PLS. No data on TDP-43 immunohistochemical findings have been reported to date.


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