Which histologic findings are characteristic of primary lateral sclerosis (PLS)?

Updated: Apr 28, 2014
  • Author: Hidehiro Takei, MD; Chief Editor: Adekunle M Adesina, MD, PhD  more...
  • Print
Answer

Answer

Degeneration in primary lateral sclerosis (PLS) is confined to UMNs, including their descending motor tracts (see the images below). No loss or degeneration of LMNs or gliosis is seen in the spinal anterior horns. No BBs are identified.

Primary lateral sclerosis. Histologic features of Primary lateral sclerosis. Histologic features of spinal cord with degenerated lateral column (arrows) are seen in this image. (Luxol fast blue stain, ×40)
Primary lateral sclerosis. Histologic features of Primary lateral sclerosis. Histologic features of spinal cord with well-preserved anterior horn neurons (arrowheads) are seen in this image. (Luxol fast blue plus eosin stain, ×100)

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!