Which gross findings are characteristic of primary lateral sclerosis (PLS)?

Updated: Apr 28, 2014
  • Author: Hidehiro Takei, MD; Chief Editor: Adekunle M Adesina, MD, PhD  more...
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No valid autopsy findings of pure primary lateral sclerosis (PLS), excluding upper motor neuron (UMN)–dominant ALS cases, have been reported to date. Theoretically, however, neither atrophy of the anterior nerve roots nor widespread muscle atrophy or wasting is seen.

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