Which medications in the drug class Antiemetic Agents are used in the treatment of Pediatric Headache?

Updated: Jan 02, 2019
  • Author: J Ivan Lopez, MD, FAAN, FAHS; Chief Editor: George I Jallo, MD  more...
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Antiemetic Agents

Antiemetics are useful in the treatment of symptomatic nausea. Interestingly, sometimes the GI symptoms of migraine, as opposed to the pain, are at the forefront of the clinical picture and require the most attention. This can significantly differ from the management of adults with migraine. Delayed gastric peristalsis can hinder medication absorption. [59]

Promethazine (Phenergan, Promethegan, Phenadoz)

Promethazine blocks the postsynaptic mesolimbic dopaminergic receptors in the brain and reduces stimuli to the brain-stem reticular system. It has antiemetic and antihistaminic actions that alleviate nausea and vomiting and promote sleep. Because of its antidopamine action, promethazine also has a direct antimigraine effect. It is usually well tolerated.

Metoclopramide (Reglan, Metozolv ODT)

Metoclopramide promotes gastric emptying and has antiemetic effects, which are useful for treating the nausea and vomiting associated with migraine.

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