Which medications in the drug class Beta-Blockers are used in the treatment of Pediatric Headache?

Updated: Jan 02, 2019
  • Author: J Ivan Lopez, MD, FAAN, FAHS; Chief Editor: George I Jallo, MD  more...
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Answer

Beta-Blockers

Beta-blockers are effective in migraine prophylactic therapy, possibly by blocking vasodilators, decreasing platelet adhesiveness and aggregation, stabilizing membranes, or increasing the release of oxygen to tissues.

Propranolol (Inderal, InnoPran XL)

Taken long-term, beta-blockers such as propranolol are frequently effective in reducing the number and severity of attacks. When administering this medication, start with the lowest dose and increase the dose gradually (usually at monthly intervals) to allow each dose level to exert its maximum effect. The ideal dosage will reduce the heart rate by about 20%.

Propranolol is extensively used in migraine prevention in adults and children. Its mechanism of action in migraine prevention is supposed to be a reduction of central noradrenergic activity.

Timolol

Timolol is FDA approved for migraine prophylaxis, although there is less scientific evidence of efficacy for timolol than for propranolol.

Metoprolol (Lopressor, Toprol XL)

Metoprolol is not FDA approved for migraine prevention. It achieves efficacy in prophylactic therapy presumably by blocking vasodilators, decreasing platelet adhesiveness and aggregation, stabilizing membranes, or increasing the release of oxygen to tissues.

Nadolol (Corgard)

Nadolol is not FDA approved for migraine prevention. It achieves efficacy in prophylactic therapy presumably by blocking vasodilators, decreasing platelet adhesiveness and aggregation, stabilizing membranes, or increasing the release of oxygen to tissues.

Atenolol (Tenormin)

Atenolol is not FDA approved for migraine prevention. It achieves efficacy in prophylactic therapy presumably by blocking vasodilators, decreasing platelet adhesiveness and aggregation, stabilizing membranes, or increasing the release of oxygen to tissues.


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