Which medications in the drug class Antihistamines are used in the treatment of Pediatric Headache?

Updated: Jan 02, 2019
  • Author: J Ivan Lopez, MD, FAAN, FAHS; Chief Editor: George I Jallo, MD  more...
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Cyproheptadine is occasionally useful for migraine prophylaxis, probably because of its serotonergic (as opposed to antihistaminic) effects. Other antihistamines generally are not useful for migraine prophylaxis.


Cyproheptadine is an antihistamine that has been used for migraine prevention in children more than it has in adults. It is usually well tolerated. The mechanism by which cyproheptadine acts has not been clarified; hypotheses include antihistaminic and anti-5-HT2 effects. There is no solid scientific evidence that this medication has any value in migraine prevention, but it is used by many physicians.

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