Which medications in the drug class Ergot Derivatives are used in the treatment of Pediatric Headache?

Updated: Jan 02, 2019
  • Author: J Ivan Lopez, MD, FAAN, FAHS; Chief Editor: George I Jallo, MD  more...
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Ergot Derivatives

Ergot derivatives are not approved for children and off-label use requires close monitoring. The risk ergotism (intense vasoconstriction) may result and is typically associated with overdosage or prolonged use. Causes constriction of peripheral and central vasculature.

Dihydroergotamine (Migranal, D.H.E. 45)

Ergot derivatives include ergotamine and dihydroergotamine. Ergotamine comes only in oral form and has significant adverse effects, including vomiting, which makes it far less suitable than other drugs for the treatment of migraine.

Dihydroergotamine is used parenterally for severe migraine attacks in the adult patient and can be considered in some instances in children.

Ergotamine (Ergomar)

Ergotamine is an alpha-adrenergic and serotonin (5-HT1) antagonist and partial agonist (depending on the receptor site). It causes constriction of peripheral and cranial blood vessels. This agent works best when it is used in the early stages of migraine. Significant nausea and vomiting have been associated with its use.

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