What is the role of isometheptene (Midrin) and ergotamines in the treatment of pediatric headache?

Updated: Jan 02, 2019
  • Author: J Ivan Lopez, MD, FAAN, FAHS; Chief Editor: George I Jallo, MD  more...
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Isometheptene (Midrin) and ergotamines are also available for abortive migraine therapy (Although Midrin was removed from the US market in 2011, a generic form has appeared on the market.). While scientific evidence for their efficacy is lacking, many clinicians have used these medications with success. They are most effective when administered at aura onset or at the start of the headache. Because aura is less common in pediatric migraine and because children may be less able to communicate early symptoms of a headache, administering these abortive therapies at the appropriate time can be difficult.

Ergotamines generally are not used for young children (aged 6 years or younger) and may cause GI upset.

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