What methods are used to reverse anticoagulation due to factor Xa in the treatment of hereditary and acquired hypercoagulability?

Updated: Jan 05, 2018
  • Author: Paul Schick, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

No antidote for factor Xa inhibitors (eg, fondaparinux, rivaroxaban) is currently available. The long half-lives of LMWH and fondaparinux and the possibility of continued release into the circulation from the site of subcutaneous injection further complicates the reversal process.

Likewise, no antidotes are available for lepirudin, bivalirudin, and argatroban, or for the oral direct thrombin inhibitors that are currently in clinical trials.


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