How bleeding episodes managed in hereditary and acquired hypercoagulability?

Updated: Jan 05, 2018
  • Author: Paul Schick, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

A major consideration in the administration of anticoagulants is the reversal of anticoagulation in patients who bleed. All currently available anticoagulants carry similar risks of serious bleeding episodes. Unfractionated heparin is readily reversible with protamine, but protamine carries some risk of hypotensive and anaphylactic reactions. Warfarin can be reversed in a short time by the administration of fresh frozen plasma, but reversal with vitamin K can take several hours.


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