What are the advantages of direct factor Xa inhibitors and direct thrombin inhibitors in the treatment of hereditary and acquired hypercoagulability?

Updated: Jan 05, 2018
  • Author: Paul Schick, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Direct oral anticoagulants have several possible advantages over warfarin, including the following:

  • No or limited interaction with other drugs and diet
  • Metabolic half-lives that allow for once- or twice-daily dosing
  • No need to monitor due to predictable pharmacokinetics
  • Possibly less bleeding complications

However, continued evaluation of the value of direct oral anticoagulants in complex thrombotic syndromes (eg, antiphospholipid antibody syndrome) and cancer patients is important before these agents are widely used in these complex cases.


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