What is the basis for the decision to institute long-term or extended anticoagulation in patients with lupus anticoagulants in hereditary and acquired hypercoagulability?

Updated: Jan 05, 2018
  • Author: Paul Schick, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Some organizations recommend that patients with lupus anticoagulants be treated more aggressively. For example, the American College of Chest Physicians recommends 12 months of anticoagulation and consideration of long-term anticoagulation after a single thrombotic event in patients with antiphospholipid syndrome. [29]

Recommendations conflict on the optimal international normalized ratio (INR) level in patients with lupus anticoagulants who are on warfarin. In most cases, an INR of 2.0 to 3.0 is adequate. However, a higher INR might be desirable in patients with severe recurrent thromboembolic disease.

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