Which studies are performed in a diagnosis of a protein S deficiency in hereditary and acquired hypercoagulability?

Updated: Jan 05, 2018
  • Author: Paul Schick, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

For protein S deficiency, free antigen, total antigen, and functional assays are available. All three should be performed, because variants of protein S deficiency include the following:

  • Low total protein S, normal free protein S
  • Low-normal total protein S, low free protein S
  • Normal total and free protein S, functionally abnormal protein S

For full discussion, see Protein S Deficiency.


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