Which lab results suggest factor V Leiden APC resistance in hereditary and acquired hypercoagulability?

Updated: Jan 05, 2018
  • Author: Paul Schick, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

A ratio of <2.3 suggests abnormal resistance to APC of hereditary origin. In patients who carry the factor V Leiden mutation, those who are homozygous have a very low APC resistance ratio, typically 1.1 to 1.4, while in heterozygous carriers  the ratio is usually 1.5 to 1.8. [12]

Patients with an abnormally low APC resistance assay result should undergo genetic testing for factor V Leiden. This test, which is a polymerase chain reaction (PCR) assay, can identify carriers and determine whether they are heterozygous or homozygous.


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