Which lab tests are performed in patients with suspected factor V Leiden?

Updated: Jan 05, 2018
  • Author: Paul Schick, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

In patients with suspected factor V Leiden, coagulation testing with an activated protein C (APC) resistance assay should be done first, because a small fraction of APC resistance disorders are due to mutations other that factor V Leiden. In this assay, the ratio of aPTT testing performed with and without added APC is reported as the APC resistance (or sensitivity) ratio. [12]


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