How is the diagnosis of antiphospholipid syndrome (lupus anticoagulant) confirmed in hereditary and acquired hypercoagulability?

Updated: Jan 05, 2018
  • Author: Paul Schick, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Confirmation of the diagnosis is based on the following study results:

  • Prolonged phospholipid-dependent dilute Russell viper venom time (dRVVT), Increased titers of anticardiolipin antibodies (IgG and IgM)
  • Increased titers of anti-β(2)glycoprotein 1 antibodies (IgG and IgM)

Confirmatory test results should be positive on two occasions 12 weeks apart. Efforts to standardize these tests have been made, to enable reliable diagnosis of lupus anticoagulants and prediction of the risk for thrombosis. It has been suggested that the risk of thrombosis is greater when results from several of these tests are positive. [24]

For full discussion, see Antiphospholipid Syndrome and Antiphospholipid Antibody Syndrome and Pregnancy

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