What are the Sapporo diagnostic criteria for antiphospholipid syndrome?

Updated: Jan 05, 2018
  • Author: Paul Schick, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Clinical criteria for indicating the presence of lupus anticoagulants (Sapporo criteria for the antiphospholipid syndrome) are as follows:

  • One or more episodes of arterial, venous, or small-vessel thrombosis, affecting any organ or tissue
  • Pregnancy morbidity: The risk for maternal and fetal morbidity increases after the 10th week of pregnancy; fetal mortality in pregnancy can include spontaneous abortions, prematurity, and stillbirths
  • Three or more unexplained consecutive spontaneous abortions after the 10th week of gestation

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