What is the incidence of venous thromboembolism in first-degree relatives of patients with hereditary and acquired hypercoagulability?

Updated: Jan 05, 2018
  • Author: Paul Schick, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

A study by Couturaud et al sought to identify risk factors and quantify the risk of venous thromboembolism in first-degree relatives of patients with a first episode of unprovoked venous thromboembolism. [14] The investigators found a prevalence of 5.3% of previous venous thromboembolism in the first-degree relatives. The strongest predictor of venous thromboembolism in this group was thrombosis at a young age. However, the presence of factor V Leiden or G20210A prothrombin genes in patients were weak independent predictors of venous thromboembolism in relatives. [14]


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