What is the prevalence of hereditary and acquired hypercoagulability in the US?

Updated: Jan 05, 2018
  • Author: Paul Schick, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Lupus anticoagulants and antiphospholipid syndromes are present in 4-14% of the population. Table 1 shows the incidence of hereditary hypercoagulable disorders in the general population and the risk for thrombosis and recurrent thrombosis. [13, 14] Other underlying risk factors are elevated levels of factor VIII, fibrinogen, and other coagulation factors. Increases in type-1 plasminogen activator inhibitor (PAI-1), D-dimers, and homocysteine are also reported to be risk factors.

Table 1.  Prevalence of Acquired or Hereditary Hypercoagulable Disorders and Risks of Venous Thrombosis. (Open Table in a new window)

Condition

Prevalence in General Population (%)

Relative Risk of VTE (%)

Relative Risk of Recurrent VTE (%)

Factor V Leiden

(heterozygous)

3-7

4.3

1.3

Prothrombin 20210A

(heterozygous)

1-3

1.9

1.4

Protein C deficiency

(heterozygous)

0.02-0.05

11.3

2.5

Protein S deficiency

(heterozygous)

0.01-1

32.4

2.5

Antithrombin deficiency

(heterozygous)

0.02-0.04

17.5

2.5

VTE = Venous thromboembolism


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