When should patients be screened for factor V Leiden and prothrombin G20210A to prevent hypercoagulability?

Updated: Jan 05, 2018
  • Author: Paul Schick, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Additional risks

While persons who are heterozygous for factor V Leiden and prothrombin G20210A are at minimal risk for thrombosis, the presence of a second risk factor such as immobilization and pregnancy greatly increases the risk for thrombosis. The screening of patients for mutant Factor V and prothrombin during pregnancy and prior to initiation of hormone replacement therapy to determine whether prophylactic anticoagulation is indicated appears to be logical, but it is controversial.

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