What is the incidence of factor V Leiden in hereditary and acquired hypercoagulability?

Updated: Jan 05, 2018
  • Author: Paul Schick, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

About 5% of Caucasian Americans are heterozygous carriers of factor V Leiden. The carrier frequency among African Americans, Asian Americans, and Native Americans is less than 1% and in Hispanics is 2.5%. Carrier frequency is especially high—up to 14%—in whites of Northern European and Scandinavian ancestry. Inheritance is autosomal dominant. Most heterozygote carriers are asymptomatic while homozygotes have a high incidence of clinical thrombosis. [12]

The 5% of APC resistance not due to factor V Leiden results from a variety of factors. These include other genetic mutations, as well as acquired conditions such as pregnancy, oral contraceptives, and lupus anticoagulant, all of which may also cause APC resistance. [12]


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