What is the role of factor V Leiden resistance in the pathogenesis of hypercoagulability?

Updated: Jan 05, 2018
  • Author: Paul Schick, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Factor V Leiden is resistant to APC and hence not inactivated (APC resistant). About 20-60% of patients with thromboembolism have a form of APC resistance, and factor V Leiden is responsible for 95% of APC resistance.


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