What is the role of genetics in the pathogenesis of hypercoagulability?

Updated: Jan 05, 2018
  • Author: Paul Schick, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

In addition to thrombophilias resulting from individual mutations, an inherited susceptibility to venous thromboembolism may result from multigenic action. Research on multiple polymorphisms within the anticoagulant, procoagulant, fibrinolytic, and innate immunity pathways confirms a complex interrelationship that appears to increase the risk of venous thromboembolism. [10]


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