What is the pathophysiology of hereditary and acquired hypercoagulability in lupus?

Updated: Jan 05, 2018
  • Author: Paul Schick, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Lupus anticoagulants are antiphospholipid antibodies that are associated with acquired hypercoagulability. The mechanisms for hypercoagulability in these patients remains poorly understood, but alteration of the regulation of hemostasis and endothelial cell injury might be responsible. [6, 7, 8] The inappropriate name for these antibodies is due to their initial discovery in patients with lupus—although they can also occur in individuals without lupus—and to their anticoagulant effect in vitro.


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