What is the role of endothelial injury in the pathogenesis of hereditary and acquired hypercoagulability?

Updated: Jan 05, 2018
  • Author: Paul Schick, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Normal endothelium provides a non-thrombotic surface. Injury to endothelium is accompanied by loss of protective molecules and expression of adhesive molecules, procoagulant activity, and mitogenic factors, leading to development of thrombosis, smooth muscle cell migration, and proliferation and atherosclerosis. [3] In Behcet disease, a generalized autoimmune vasculitis and endothelial dysfunction occurs, with protean consequences that include  thrombosis, mucocutaneous lesions, uveitis, and neurological abnormalities.


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