What is the role of the Virchow triad in the pathogenesis of hereditary and acquired hypercoagulability?

Updated: Jan 05, 2018
  • Author: Paul Schick, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Hemostasis is highly regulated to maintain a delicate balance between controlling bleeding in response to injury and avoiding excess procoagulant activity, to prevent hypercoagulability and thrombosis. The Virchow triad identifies the three underlying factors that are thought to contribute to thrombosis: hypercoagulability, hemodynamic dysfunction (ie, stasis—from immobilization or peripheral venous obstruction—or turbulence), and endothelial injury/dysfunction.


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