Which histologic findings are characteristic of Kikuchi disease?

Updated: Nov 13, 2020
  • Author: John Boone, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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Immunohistochemical studies reveal the following:

  • The immunophenotype of Kikuchi disease is primarily composed of mature CD8-positive and CD4-positive T lymphocytes; lymphocytes and histiocytes also exhibit a high rate of apoptosis

  • Relatively few B cells and natural killer (NK) cells are present

  • Positive immunostaining results by monoclonal antibody Ki-M1P are seen in Kikuchi disease but not in malignant lymphoma

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