What are the signs and symptoms of Kikuchi disease?

Updated: Nov 13, 2020
  • Author: John Boone, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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Kikuchi disease most frequently manifests as a relatively acute onset of cervical adenopathy associated with fever and a flulike prodrome.

Lymphadenopathy features are as follows:

  • Cervical nodes are affected in about 80% of cases
  • Posterior cervical nodes are frequently involved (65-70% of cases)
  • Lymphadenopathy is isolated to a single location in 83% of cases, but multiple chains may be involved
  • Cases of generalized adenopathy involving axillary, inguinal, and mesenteric nodes are unusual

A flulike prodrome with fever is present in 50% of cases. The following are less common signs and symptoms:

  • Headache
  • Nausea, vomiting
  • Malaise, fatigue
  • Weight loss
  • Arthralgias, myalgias
  • Night sweats
  • Rash (up to 30%)
  • Thoracic/abdominal pain

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