What are the sexual predilections of Kikuchi disease?

Updated: Nov 13, 2020
  • Author: John Boone, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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Answer

Kikuchi disease is reported more often in women, with a female-to-male ratio as high as 4:1 in some studies. [2] However, other studies have shown a smaller female preponderance, with a ratio closer to 2:1. [24]

A study of Korean patients by Jung et al reported clinical differences between males and females with Kikuchi disease. Females were more likely to have autoimmune features, including antinuclear antibodies, while males were more likely to present with a profile of fever, headache, bilateral lymphadenopathy, thrombocytopenia, and elevated levels of liver enzymes, C-reactive protein, and lactate dehydrogenase (LDH). [25]


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