What is Waterhouse-Friderichsen syndrome?

Updated: Oct 28, 2019
  • Author: Muhammad A Mir, MD, FACP; Chief Editor: Perumal Thiagarajan, MD  more...
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Answer

Answer

Waterhouse-Friderichsen syndrome is characterized by the abrupt onset of fever, petechiae, arthralgia, weakness, and myalgias, followed by acute hemorrhagic necrosis of the adrenal glands and severe cardiovascular dysfunction. The syndrome is most often associated with meningococcal septicemia but may complicate sepsis caused by other organisms, including certain streptococcal species. This disorder may be associated with a history of splenectomy. [27]


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