What is the role of abnormal circulating proteins in the etiology of nonplatelet hemostatic disorders?

Updated: Oct 28, 2019
  • Author: Muhammad A Mir, MD, FACP; Chief Editor: Perumal Thiagarajan, MD  more...
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Answer

Abnormal circulating proteins may precipitate in the microvasculature, leading to localized thrombosis. These thromboses may be monoclonal, such as those produced in multiple myeloma and Waldenstrom macroglobulinemia, or they may be polyclonal, such as those found in the cryoglobulinemias. [18] Abnormal circulating proteins are associated with infectious, autoimmune, and neoplastic disorders. Patients typically present with purpuric skin rash, urticaria, arthralgia, motor-sensory polyneuropathy, and diffuse proliferative glomerulonephritis. Laboratory findings may indicate anemia, rheumatoid factor, and decreased complement levels, as well as abnormal populations of paraproteins and/or immunoglobulins. [19, 20]


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