How are fibrinogen disorders treated?

Updated: Oct 06, 2020
  • Author: Irene S Pakos, DO; Chief Editor: Perumal Thiagarajan, MD  more...
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Answer

Answer

Treatment of afibrinogenemia/dysfibrinogenemia depends on the presenting clinical setting. Plasma fibrinogen is best replaced by cryoprecipitate. Purified, virally inactivated fibrinogen concentrates (eg, RiaSTAP) can be used if available. [22, 23]

Prophylactic administration of blood product or fibrinogen therapy has no role. Recommendations for a desired plasma fibrinogen level for specific conditions are difficult to find because most physicians rely on correction of the clinical hemostatic abnormality as an endpoint. Kobayashi et al recommend that the fibrinogen level must be at least 0.60 g/L and, if possible, more than 1 g/L during pregnancy in patients with congenital afibrinogenemia. These authors maintain a plasma level of 150-200 g/dL during labor to prevent placental abruption.


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