Which clinical history findings are characteristic of fibrinogen disorders?

Updated: Oct 06, 2020
  • Author: Irene S Pakos, DO; Chief Editor: Perumal Thiagarajan, MD  more...
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While most patients with dysfibrinogenemia are clinically asymptomatic, some present with a bleeding diathesis, others with thrombophilia, and others with both bleeding and thromboembolism. [5]

Approximately half of the mutations are clinically silent. Hemorrhage and thrombosis occur in almost equal numbers of cases. Severe bleeding is rare and is typically limited to postpartum bleeding, although isolated cases of patients with intraabdominal hemorrhage presenting with acute abdomen have been reported. [9, 10, 11] Dysfibrinogenemias present particular problems for the obstetrician because women affected by these disorders are at increased risk of first-trimester bleeding, spontaneous abortion, and/or postpartum thrombosis. [14]

The diagnosis of afibrinogenemia/dysfibrinogenemia should be considered in a patient who has bleeding or thrombosis unexplained by other common causes. A high level of clinical suspicion should be maintained in patients with other inherited disorders of hemostasis, such as protein C or S deficiency.

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