How is the intravenous immunoglobulin (IVIG) administered to patients?

Updated: Jul 05, 2018
  • Author: Jessica Katz, MD, PhD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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IVIG liquid products that have been stored in refrigerators should be allowed to come to room temperature before administration to minimize adverse effects.

IVIG is usually administered at an infusion center or healthcare facility. However IVIG may be infused in the home setting, usually by an experienced infusion nurse.

Patients receiving IVIG should be well hydrated prior to infusion. This is particularly important for patients with risk factors for thrombosis and/or renal complications of IVIG therapy.

Dosing varies upon whether IVIG is administered for the purpose of reducing infections or suppression of an inflammatory of autoimmune process. IVIG doses range from 400 to 800 mg/kg/month are used for immune deficiencies. Doses may be given every three to four weeks. In patients who require auto-inflammatory effects of IVIG, high doses are typically required. This will usually range from 1-2 g/kg as a single dose.

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