What are the uses of intravenous immunoglobulin (IVIG)?

Updated: Jul 05, 2018
  • Author: Jessica Katz, MD, PhD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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IVIG is used to treat various autoimmune, infectious, and idiopathic diseases. IVIG is an approved treatment for multifocal motor neuropathy, chronic lymphocytic lymphoma, chronic inflammatory demyelinating polyneuropathy, Kawasaki disease and ITP. The beneficial effects of an intramuscular injection of immune globulin for the prophylactic treatment of patients with primary immunodeficiency syndromes are well established. The therapeutic effects of IVIG go beyond antibody replacement in those patients with antibody deficiency. The number of inflammatory and autoimmune diseases (especially when it is administered intravenously) for which IVIG is used has expanded enormously. These diverse disorders range from blistering skin diseases to transplant rejection, neurologic diseases. It is widely accepted for use in persons with multiple other diseases including, but not limited to, Guillain-Barré syndrome, multiple myeloma, myasthenia gravis, acquired factor VIII inhibitor syndrome, autoimmune neutropenia, post-transfusion purpura, and polymyositis/dermatomyositis.

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