What is the efficacy of intravenous immunoglobulin (IVIG) for the treatment of ITP?

Updated: Jul 05, 2018
  • Author: Jessica Katz, MD, PhD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

There are now multiple alternative IVIG preparations available for intravenous administration that have been approved by the Food and Drug Administration (FDA) for the treatment of primary humoral immunodeficiencies and chronic immune thrombocytopenic purpura. Also, a liquid, pasteurized, 10% concentrated intravenous gammaglobulin preparation is as effective as a 5% concentrated preparation, making the concentrated versions more convenient to administer.

The image below is a schematic representation of an immunoglobulin G molecule.

Schematic representation of an immunoglobulin G mo Schematic representation of an immunoglobulin G molecule. CH indicates constant region of heavy chain; CL, constant region of light chain; VH, variable region of heavy chain; and VL, variable region of light chain.

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