What is the prognosis of severe combined immunodeficiency (SCID)?

Updated: Aug 11, 2020
  • Author: Francisco J Hernandez-Ilizaliturri, MD; Chief Editor: Emmanuel C Besa, MD  more...
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  • Without treatment, most of the patients with combined B-cell and T-cell disorders die within the first 6 months.

  • Patients who are well nourished, uninfected, and younger than 6 months before transplantation have the best outcomes.

  • Patients with SCID barely survive without stem cell reconstitution. However, gene therapy is an alternative for those cases in which donors are unavailable.

  • Patients with less severe mutations in the ADA gene have survived into adulthood.

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