What are the possible complications of severe combined immunodeficiency (SCID)?

Updated: May 27, 2020
  • Author: Francisco J Hernandez-Ilizaliturri, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

See the list below:

  • Bronchiectasis and cor pulmonale complicate chronic/recurrent lower respiratory tract infections.

  • Hearing loss due to chronic otitis media or meningoencephalitis may affect as many as one third of patients with XLA.

  • The risk of GVHD is high in patients with SCID because of their inability to reject foreign antigens.

  • EBV-associated smooth muscle tumors may occur in patients who are partially reconstituted after bone marrow transplantation for SCID and who may not require surgery or chemotherapy. [29]

  • Central nervous system viral infection is one of the most potentially devastating complications of immunodeficiency, but this is a rare presentation in patients with SCID.


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