What is included in the long-term monitoring of severe combined immunodeficiency (SCID)?

Updated: Aug 11, 2020
  • Author: Francisco J Hernandez-Ilizaliturri, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Regularly monitor the following in patients with severe combined immunodeficiency:

  • Growth and development
  • Chest radiographs
  • Pulmonary function
  • Immunoglobulin trough levels
  • Liver function

Imunoglobulin trough levels of 400 mg/dL or higher are considered satisfactory. Occasionally, levels greater than 500 mg/dL are required to clear certain viral infections, such as enterovirus meningoencephalitis. Trough levels may need to be titrated in individual patients to determine the level that is needed to prevent recurrent infection.

If abnormalities are identified on liver function tests, imaging studies of the liver and biliary tree are necessary to exclude malignancies or sclerosing cholangitis (the latter is observed in patients with X-linked immunodeficiency with hyper IgM syndrome [XHM]).


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