When was factor X deficiency first recognized?

Updated: Feb 18, 2020
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Perumal Thiagarajan, MD  more...
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In the 1950s, two independent groups first identified factor X deficiency. Telfer and colleagues reported a bleeding tendency in a 22-year-old woman named Prower in 1956 [6] ; Hougie and colleagues described abnormal coagulation profiles in a 36-year-old man named Stuart in 1957. [7] Experiments demonstrated that mixing plasma or serum from Stuart and Prower did not mutually correct the abnormality, thus showing that the two lacked an identical factor. Based on these common clotting test results, the factor was designated Stuart-Prower factor. This factor became known as factor X.

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