What is the reference range of procalcitonin (PCT)?

Updated: Jul 30, 2019
  • Author: Jiun-Lih Jerry Lin, MBBS, MS(Orth); Chief Editor: Eric B Staros, MD  more...
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Answer

Answer

Procalcitonin (PCT), a protein that consists of 116 amino acids, is the peptide precursor of calcitonin, a hormone that is synthesized by the parafollicular C cells of the thyroid and involved in calcium homeostasis. Procalcitonin arises from endopeptidase-cleaved preprocalcitonin.

The reference value of PCT in adults and children older than 72 hours is 0.15 ng/mL or less.

Reference values for PCT have not been established in infants younger than 72 hours.

In healthy adults, the reference range of PCT is below the level of detection. [1]

The half-life of PCT is 25-30 hours (not significantly altered in individuals with renal dysfunction). [2]


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