Which clinical history findings are characteristic of factor V deficiency?

Updated: Mar 09, 2021
  • Author: Olga Kozyreva, MD; Chief Editor: Perumal Thiagarajan, MD  more...
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Answer

Clinical manifestations of factor V deficiency include the following:

  • Bleeding into the skin

  • Excessive bruising with minor injuries

  • Nosebleeds

  • Bleeding gums

  • Excessive menstrual bleeding and prolonged or excessive loss of blood with surgery or trauma

  • Bleeding in mucosal tracts (gastrointestinal, urinary)

  • Hemarthrosis and flexion contracture

  • Bleeding during delivery and postpartum [17]

  • Intracerebral hemorrhages [18, 19]

  • Pulmonary hemorrhage [20]

The severity of bleeding symptoms is only partly related to the degree of factor V deficiency in plasma. Some patients with undetectable plasma levels of factor V experience only relatively mild bleeding. [1]


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