How are the results of C-terminal telopeptide measurement interpreted?

Updated: Feb 18, 2020
  • Author: Carlos Solano Loran, MD; Chief Editor: Eric B Staros, MD  more...
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Answer

Answer

C-terminal telopeptide levels may indicate the following:

  • Elevated levels of C-terminal telopeptide indicate increased bone turnover.

  • Elevated levels are found in osteoporosis patients with elevated bone turnover who are at increased risk for rapid disease progression.

  • Increased levels are also associated with osteopenia, Paget disease of the bone, hyperthyroidism, and hypothyroidism.

  • This test can be used to monitor and assess how effective antiresorptive therapy has been in patients treated for disorders such as osteopenia, osteoporosis, and Paget disease.

  • This test can also serve as an adjunct means of monitoring patient response to other treatments for diseases with increased bone turnover, such as rickets, osteomalacia, and hyperthyroidism.

  • Using pretreatment beta–C-telopeptide of type 1 collagen (beta-CTX) levels as a baseline, adequate therapeutic response is indicated by a decrease of 25% or more 3-6 months after the initiation of therapy.


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